Molecular Psychiatry

Molecular Psychiatry

Our group investigates a number of psychiatric and related illnesses including drug abuse, autism, sleep and schizophrenia. We are also interested in basic neuroscience, including understanding the mechanisms involved in neurotransmitter release and synaptic plasticity. Our research uses numerous cutting-edge techniques from genome-wide association studies (GWAS), through brain slices (voltammetry and patch-clamp) to rodent behavioural models.

Activities of the Team

Prof Colin Davidson (group lead) studies the neurochemistry of drugs of abuse and is currently focussing on legal highs. He uses Fast cyclic voltammetry to detect levels of dopamine, 5-HT and noradrenaline in rodent tissue. He is also interested in the presynaptic control of transmitter release and the interactions between reuptake sites, autoreceptors and transmitter efflux. He has studied these mechanisms in relation to antidepressant action.

Dr Anthony Ashton’s group investigates the precise neuronal components that contribute to neurotransmitter release. Their current projects involve investigating: (i) the control of distinct modes of synaptic vesicle exocytosis; (ii) the relationship of these modes with different synaptic vesicle pools; (iii) the properties of the silent pool of vesicles.

The aim of these studies is to determine how these are normally regulated and whether in neuronal dysfunction their properties are disturbed.

Dr Victorio Bambini Junior is a specialist in animal behaviour and in neuroimmunology. He is interested in neurodevelopmental disorders, especially autism spectrum disorders (ASD), and in the analysis of the interface between immunological alterations and complex neural outcomes. He is part of the Brazilian National Institute of Neuroimmunology (FIOCRUZ – RJ, Brazil), GETTEA (Group of Translational Studies in Autism Spectrum Disorder, Clinical Hospital of Porto Alegre – RS, Brazil) and is responsible for the Laboratory of Behavioural Observation at UCLan.

Dr Inma Gonzalez research is focus on the mechanisms by which neurotransmitter receptors are targeted to, retained at and removed from the synapses under physiologycal and physiopathological conditions. Understanding this processes will give us important insights into synapse formation, stabilisation and the plasticity events underlying cognition in health and disease.

Dr Jamal Nasir has an interest in the genetics of Neuropsychiatric disorders and also has an interest in dopamine signalling especially with respect to schizophrenia and drug abuse. More recently, he and his team have been exploring the genetics of neurodevelopmental disorders through investigating consanguineous populations and has undertaken functional studies of the relevant genes and their roles in various processes in the cell through external collaborations.  Dr Nasir has also been investigated the dopamine signalling pathway at the molecular level and identified novel dopamine receptor interacting proteins (DRIPs).  Finally, in collaboration with researchers at UCL, Dr Nasir is undertaking genomics and proteomics studies of stroke and various other conditions, including ALS, schizophrenia and Parkinson’s disease.

Dr Robert Sims has a research focus in the physiology of homeostatic sleep and adenosine metabolism in the basal forebrain, although extensive experience in synaptic transmission and plasticity. Working with Prof. Nicholas Dale at Warwick University he developed a novel in vitro model for investigating sleep. He is skilled in experimental techniques such as electrophysiology, fluorescence imaging, optogenics and microelectrode biosensors.

Dr Chris Smith’s experience of in vivo microdialysis can be applied to disparate conditions from glioma to Alzheimer’s disease where the neurochemistry of the brain can be monitored in situ in the living organism as the disease progresses. In addition the technique can be used to determine the effect pharmacological agents would have on the release of neurotransmitters. A powerful aspect of in vivo pharmacology is combining microdialysis with behavioural studies to correlate the brain neurochemistry with behaviour, an ambition that is currently being worked towards.

Dr Milos Petrovic and Dr Craig Bertram are engaged in the Parkinson’s disease research as well as the disturbance of glutamatergic signalling in dementia models.

Dr Vicky Jones is focused on the role of glia in the pathogenesis of dementias. Dr Jones’ recent work described the production of induced pluripotent stem cells (iPSCs) from patients with both late- and early-onset Alzheimer’s disease (LOAD and EOAD, respectively), their subsequent differentiation into mature astrocytes and detailed morphological characterisation using microscopic 3D analysis. This work saw the first description of AD-associated astrocytic atrophy in human cells and in LOAD (having previously only been described in mouse models of EOAD).

Meet The Team

Senior members of the Group include