MSc By Research
MSc By Research
The MSc (by Research) is very similar to a PhD, but with a research project designed to take 12 months. It is not intended as a first step towards a PhD, but rather as an alternative to a PhD. There are no associated lectures, classes or written examinations. However, if you wish, you can still decide to change programme and register for MPhil/PhD and use your MSc (by Research) year as the first year of a PhD. The project can be in any of the subject areas for which supervision is available.
The projects available for the MSc (by Research) do not cover all subject areas, therefore it is recommended that you enquire whether the MSc (by Research) can be offered in an area/s of your choice before you apply. Please contact Research Admissions at ResearchAdmissions@uclan.ac.uk to discuss further.
Epigenetic and cellular mechanisms underlying memory impairment in mouse models of Alzheimer’s disease
Beglopoulos V, Tulloch J, Roe AD, Daumas S, Ferrington L, Watson R, Fan Z, Hyman BT, Kelly PAT, Bard F, and Morris RGM. (2016) Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice. Nature Communications 7:11761, 1-10.
Examining the neuropharmacology of psychostimulants MA. Sahai, C Davidson, G Khelashvili, V Barrese, N Dutta, H Weinstein, J Opacka-Juffry (2016) Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances – The case of the benzofuran 5-MAPB. Progress in Neuro-Psychopharmacology & Biological Psychiatry 75, 1-9. Modelling stroke in brain slices Baresse V, Greenwood IA, Davidson C (2015) Protective role of Kv7 channels in anoxia-induced damage in caudate brain slices. J Cerebral Blood Flow Metab 35, 1593-600. Modelling psychiatric conditions in invertebrates J Prados, B Alvarez, J Howarth, K Stewart, CL Gibson, CV Hutchinson, AMJ Young & C Davidson (2013) Cue competition effects in the planarian. Animal Cognition 16, 177-186.
In vitro simulation of patient breathing profiles. In vitro / in vivo correlation of breathing pattern and lung deposition. Paediatric use of spacers with pressurised metered dose inhalers – a computational fluid dynamics approach
Computer-aided drug design targeting glycogen phosphorylase, a target for type 2 diabetes and cancer treatment Kun S, Begum J, Kyriakis E, Stamati ECV, Barkas TA, Szennyes E, Bokor E, Szabó KE, Stravodimos GA, Sipos A, Docsa T, Gergely P, Moffatt C, Patraskaki MS, Kokolaki MC, Gkerdi A, Skamnaki VT, Leonidas DD*, Somsák L*, Hayes JM*. “A multidisciplinary study of 3-(b-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors”, Eur. J. Med. Chem. (2018), 147, 266-278.
In silico design and synthesis of natural product based inhibitors of glycogen phosphorylase. Hayes JM*, Kantsadi N, Leonidas DD*, “Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes”, Phytochem. Rev., 2014, 13, 471-498.
Exploring the role of Alzheimer-associated genes in astrocyte function New molecular markers for brain tumours Targeting reactive astrocytes as therapies for neurodegeneration, chronic pain and paralysis Diagnostic biomarkers for motor neurone disease Molecular determinants of astrocyte morphology in health and disease Developing biomarkers for the diagnosis and prognosis of brain tumours
Peptides based on Amyloid β for studies and treatment of Alzheimer’s disease. M.J. Krysmann, V. Castelletto and I.W. Hamley Fibrillisation of hydrophobically modified amyloid peptide fragments in an organic solvent, Soft Matter, 2007, 3, 1401-1406. M.J. Krysmann, V. Castelletto, A. Kelarakis, I.W. Hamley, R. Hule, D.J. Pochan Self-Assembly and Hydrogelation of an Amyloid Peptide Fragment, Biochemistry 2008, 47, 4597-4605. Nanomaterials for bioimaging; bringing light to medicine.Marta J. Krysmann, Antonios Kelarakis, Panagiotis Dallas, Emmanuel P. Giannelis Formation Mechanism of Carbogenic Nanoparticles with Dual Photoluminescence Emission, JACS 2012, 134, 747-750. A. Bourlinos, A. Bakandritsos, A. Kouloumpis, D. Gournis, M. Krysmann, E. Giannelis, K. Polakova, K. Safarova, K. Hola, R. Zboril Gd(III)-Doped Carbon Dots as a Dual Fluorescent-MRI Probe Chemistry of Materials J. Mater. Chem., 2012, 22, 23327. Think big, aim small! Development of novel antimicrobial materials.
D. Fernandes, , W. Kluska, , J. Stanislawska, , B. Board, , M.J. Krysmann, A. Kelarakis Novel hydrogels containing Nafion and poly(ethylene oxide) based block copolymers Polymer 2017, 114, 73-78.
Molecular mechanisms of anti-social behaviours and enhanced cognition.
Daumas S*, Hunter CJ*, Mistry RB*, Morè L*, Privitera L*, Cooper DD, Reyskens KM, Flynn HT, Morris RG, Arthur JS, Frenguelli BG.(2017).The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory. eNeuro 4(1). pii: ENEURO.0212-16.2017.
Aptamers in the diagnosis and treatment of glioma Shraddha Aptekar, Clare Louise Lawrence, Robert William Lea, Jane Elizabeth Alder and Lisa Shaw 2015. Selective targeting to glioma with nucleic acid aptamers. PLoS One. Aug 7;10(8):e0134957. doi: 10.1371/journal.pone.0134957. eCollection 2015 Role of dysregulated miRNA in glioma Josie L Hayes; Helene Thygesen; Charlotte Bellamy; Alastair Droop; Marjorie Boissinot; Thomas Hughes; David Westhead; Lisa Shaw; Jane Alder; Susan Short; Sean Lawler (2015). Robust prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature. Mol Oncol. 2015 Mar;9(3):704-14 Characterisation of in vivo models of brain tumours
The synthesis and in-vitro antiproliferative activity of small heterocycles against glioblastoma multiforme C Sherer, I Tolaymat, F Rowther, T Warr, T Snape (2017) Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells. Bioorg. Med. Chem. Lett., 27, 7, 1561-1565. Synthesis of amphiphilic guanidine oligomers as potential membrane interactive compounds for the treatment of brain tumours Y Patil-Sen, S Dennison and T Snape (2016) Functional foldamers that target bacterial membranes: the effect of charge, amphiphilicity and conformation. Bioorg. Med. Chem., 24, 4241-4245. S Fahs, F Rowther, S Dennison, Y Patil-Sen, T Warr, T Snape (2014) Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity, Bioorg. Med. Chem. Lett., 24, 15, 3430–3433.
Epidemiology of Campylobacter jejuni enteritis
Dingle, K.E., Colles, F.M., Wareing, D.R., Ure, R., Fox, A.J., Bolton, F.E., Bootsma, H.J., Willems, R.J., Urwin, R. and Maiden, M.C. (2001) Multilocus sequence typing system for Campylobacter jejuni, Journal of clinical microbiology, 39(1), pp. 14-23. Wareing, D.R., Bolton, F.J., Fox, A.J., Wright, P.A. and Greenway, D.L. (2002) ‘Phenotypic diversity of Campylobacter isolates from sporadic cases of human enteritis in the UK’, Journal of applied microbiology, 92(3), pp. 502-509.
Graduates from MSc (by Research) degrees tend to go on to further research (e.g. PhD) or careers in industry. Please see our Case Studies page for details of previous research students in the Faculty.
For UK and EU applicants, entry requirements would typically be a recognised UK first degree, second class honours or above, or equivalent qualification, in a relevant subject area. Please check our latest requirements.
Funding and Costs
The latest information on fees and studentships is available on the University of Central Lancashire website.
>> Postgraduate Loans – please visit www.gov.uk to see if you are eligible
How to Apply
For the latest information on how to apply, please see our research page on the UCLan website
>> How to apply
The Faculty also offer a range of taught MSc courses. For more information, please see the UCLan course search.